Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide

A V Kolesnikov; A V Kozyr; A K Ryabko; I G Shemyakin; I A Dyatlov

doi:10.1134/S1607672917020132

Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide

Dokl Biochem Biophys. 2017 Mar;473(1):141-144. doi: 10.1134/S1607672917020132. Epub 2017 May 17.

Authors

A V Kolesnikov¹, A V Kozyr², A K Ryabko¹, I G Shemyakin¹, I A Dyatlov¹

Affiliations

¹ State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow oblast, 142279, Russia.
² State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow oblast, 142279, Russia. AVKozyr@gmail.com.

PMID: 28510135
DOI: 10.1134/S1607672917020132

Abstract

A model of a controlled conversion of polysaccharide Vi-antigen of S. typhi into zwitterionic antigen is proposed. The immunological properties of modifications of this antigen conjugated to a protein support were studied.

MeSH terms

Animals
Female
Immunity, Humoral
Immunization
Mice
Mice, Inbred BALB C
Polysaccharides, Bacterial / chemistry*
Polysaccharides, Bacterial / immunology*
Salmonella typhi / immunology*

Substances

Polysaccharides, Bacterial
capsular polysaccharide, Salmonella