Reactive Arthritis Caused by Yersinia enterocolitica Enteritis

Intern Med. 2017;56(10):1239-1242. doi: 10.2169/internalmedicine.56.7888. Epub 2017 May 15.

Abstract

We report a case of reactive arthritis (ReA) triggered by Yersinia enterocolitica enteritis. A 24-year-old Japanese man developed polyarthritis in the lower limbs. Two weeks prior to these symptoms, he noted diarrhea, right lower abdominal pain and a fever. Y. enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high anti-Y. enterocolitica antibody titer and HLA-B27 antigen positivity. Following treatment with methotrexate and steroids, his arthritis improved. This is the first reported Japanese case of ReA in the English literature after a gastrointestinal infection caused by Y. enterocolitica.

Keywords: HLA-B27; Yersinia enterocolitica enteritis; reactive arthritis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Reactive / drug therapy*
  • Arthritis, Reactive / etiology*
  • Asian People
  • Gastrointestinal Diseases / complications
  • Gastrointestinal Diseases / drug therapy
  • Humans
  • Male
  • Methotrexate / therapeutic use*
  • Prohibitins
  • Steroids / therapeutic use*
  • Treatment Outcome
  • Yersinia Infections / complications*
  • Yersinia enterocolitica / drug effects
  • Young Adult

Substances

  • Antirheumatic Agents
  • PHB2 protein, human
  • Prohibitins
  • Steroids
  • Methotrexate