Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition

Grazyna Lietzau; Vladimer Darsalia; Hiranya Pintana; Claes-Göran Östenson; Thomas Nyström; André Fisahn; Cesare Patrone

doi:10.1016/j.psyneuen.2017.04.012

Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition

Psychoneuroendocrinology. 2017 Aug:82:46-50. doi: 10.1016/j.psyneuen.2017.04.012. Epub 2017 Apr 27.

Authors

Grazyna Lietzau¹, Vladimer Darsalia², Hiranya Pintana², Claes-Göran Östenson³, Thomas Nyström², André Fisahn⁴, Cesare Patrone⁵

Affiliations

¹ Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden; Medical University of Gdansk, Department of Anatomy and Neurobiology, Gdansk, Poland.
² Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
⁴ Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Department NVS, Karolinska Institutet, Stockholm, Sweden. Electronic address: andre.fisahn@ki.se.
⁵ Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: cesare.patrone@ki.se.

PMID: 28501550
DOI: 10.1016/j.psyneuen.2017.04.012

Abstract

Type 2 diabetes (T2D) has been associated with cognitive decline, dementia and Alzheimer's disease (AD). Remarkably, the pathophysiological mechanisms behind this are still mostly unknown. Cognition and memory formation are associated with gamma oscillations in hippocampal neuronal networks and fast-spiking, parvalbumin-expressing interneurons (PV+ IN) play a key role in these processes.

MeSH terms

Animals
Cognition / physiology
Cognitive Dysfunction / metabolism
Diabetes Mellitus, Type 2 / complications*
Disease Models, Animal
Gamma Rhythm / physiology*
Hippocampus / metabolism
Hippocampus / physiology*
Interneurons / metabolism
Nerve Net / metabolism
Parvalbumins / metabolism
Rats
Rats, Wistar
Temporal Lobe / metabolism
gamma-Aminobutyric Acid

Substances

Parvalbumins
gamma-Aminobutyric Acid