In this work, we propose an original scheme for generic content-based retrieval of marker-based motion capture data. It works on motion capture data of arbitrary subject types and arbitrary marker attachment and labelling conventions. Specifically, we propose a novel motion signature to statistically describe both the high-level and the low-level morphological and kinematic characteristics of a motion capture sequence, and conduct the content-based retrieval by computing and ordering the motion signature distance between the query and every item in the database. The distance between two motion signatures is computed by a weighted sum of differences in separate features contained in them. For maximum retrieval performance, we propose a method to pre-learn an optimal set of weights for each type of motion in the database through biased discriminant analysis, and adaptively choose a good set of weights for any given query at the run time. Excellence of the proposed scheme is experimentally demonstrated on various data sets and performance metrics.