Activating CYSLTR2 and PLCB4 Mutations in Primary Leptomeningeal Melanocytic Tumors

Johannes A P van de Nes; Christian Koelsche; Marco Gessi; Inga Möller; Antje Sucker; Richard A Scolyer; Michael E Buckland; Torsten Pietsch; Rajmohan Murali; Dirk Schadendorf; Klaus G Griewank

doi:10.1016/j.jid.2017.04.022

Activating CYSLTR2 and PLCB4 Mutations in Primary Leptomeningeal Melanocytic Tumors

J Invest Dermatol. 2017 Sep;137(9):2033-2035. doi: 10.1016/j.jid.2017.04.022. Epub 2017 May 10.

Authors

Affiliations

¹ Institute of Pathology, Ruhr University Bochum, Bochum, Germany; Institute of Neuropathology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
² Department of Neuropathology, Ruprecht-Karls-University Heidelberg, and Clinical Cooperation Unit Neuropathology, and DKTK, DKFZ, Heidelberg, Germany.
³ Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany; Division of Histopathology, Fondazione Policlinico Universitario "A.Gemelli", Università Cattolica del Sacro Cuore, Roma, Italy.
⁴ Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
⁵ Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; The University of Sydney, Camperdown, NSW, Australia; Melanoma Institute Australia, North Sydney, NSW, Australia.
⁶ The University of Sydney, Camperdown, NSW, Australia; Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
⁷ Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
⁸ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁹ Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany; Dermatopathologie bei Mainz, Nieder-Olm, Germany. Electronic address: klaus.griewank@uk-essen.de.

No abstract available

Publication types

Letter

MeSH terms

Adult
Aged
DNA Mutational Analysis
DNA, Neoplasm / genetics*
Female
Genetic Predisposition to Disease
Humans
Male
Melanoma / genetics*
Melanoma / metabolism
Meningeal Neoplasms / genetics*
Meningeal Neoplasms / metabolism
Middle Aged
Mutation*
Phospholipase C beta / genetics*
Phospholipase C beta / metabolism
Receptors, Leukotriene / genetics*
Receptors, Leukotriene / metabolism
Young Adult

Substances

DNA, Neoplasm
Receptors, Leukotriene
cysteinyl leukotriene receptor 2
PLCB4 protein, human
Phospholipase C beta

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States