Cardio-oncology in the older adult

J Geriatr Oncol. 2017 Jul;8(4):308-314. doi: 10.1016/j.jgo.2017.04.001. Epub 2017 May 9.

Abstract

Heart disease and cancer are the leading causes of death in older adults. Many first-line cancer treatments have the potential for cardiotoxicity. Age-related risk factors, pre-existing cardiac disease, and a high prevalence of comorbidities are reasons for increased cardiotoxicity in older adults. Concerns regarding cardiotoxicity may lead to frailty bias and undertreatment, resulting in suboptimal outcomes. There is an urgent need for geriatric-specific evidence and guidelines to help tailor care for this vulnerable group. A multi-disciplinary approach based on close collaboration between oncologists, cardiologists, and geriatricians, among other specialist clinicians is essential.

Keywords: Cardio-oncology; Cardiotoxic treatments; Cardiotoxicity; Geriatrics; Older adult.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Biomarkers / blood
  • Cardiomyopathies / chemically induced
  • Cardiomyopathies / complications*
  • Cardiotoxicity / complications
  • Cardiotoxicity / diagnosis
  • Cardiotoxicity / prevention & control
  • Cardiotoxicity / therapy
  • Female
  • Heart Failure / chemically induced
  • Heart Failure / complications*
  • Humans
  • Male
  • Medical Oncology
  • Neoplasms / complications*
  • Neoplasms / therapy*
  • Radiotherapy / adverse effects*
  • Randomized Controlled Trials as Topic
  • Risk Factors

Substances

  • Antineoplastic Agents
  • Biomarkers