Epigenetics refers to the heritable information that is exclusive of DNA. Several syndromes have been found to occur as the result of the process of epigenetics. This process causes changes in the expression of genes, without changing the actual DNA sequence. The factors influencing this process include both internal and external triggers, leading to modulation of the epigenome through different mechanisms. This article aims to describe how the process of epigenetics gives rise to the multitude of possible syndromes seen in neonates. The article will also discuss the role of assisted reproductive technology may play in epigenetic changes when compared with the naturally conceived embryo.