Abstract
A new diphenyl ether 3-methylpentyl-2, 4-dichloroasterrate (2), along with a known diphenyl ether butyl 2, 4-dichloroasterrate (1) were isolated from the metabolites of a wetland fungus Aspergillus flavipes. PJ03-11. The structures of 1 and 2 were determined by extensive NMR and HR-ESI-MS experiments. Compounds 1 and 2 showed weak cytotoxic activity, but both of them showed no antimicrobial activity.
Keywords:
Aspergillus; Soil fungus; cytotoxic activity; diphenyl ether.
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Aspergillus / chemistry*
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Crystallography, X-Ray
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Drug Evaluation, Preclinical / methods
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HL-60 Cells
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Humans
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Hydroxybenzoates / chemistry
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Hydroxybenzoates / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phenyl Ethers / chemistry
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Phenyl Ethers / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Hydroxybenzoates
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Phenyl Ethers