The unification of the theory of relativity and quantum mechanics is a long-standing challenge in contemporary physics. Experimental techniques in quantum optics have only recently reached the maturity required for the investigation of quantum systems under the influence of non-inertial motion, such as being held at rest in gravitational fields, or subjected to uniform accelerations. Here, we report on experiments in which a genuine quantum state of an entangled photon pair is exposed to a series of different accelerations. We measure an entanglement witness for g-values ranging from 30 mg to up to 30 g-under free-fall as well on a spinning centrifuge-and have thus derived an upper bound on the effects of uniform acceleration on photonic entanglement.