Advances in evidence-based cancer adoptive cell therapy

Chin Clin Oncol. 2017 Apr;6(2):18. doi: 10.21037/cco.2017.02.07.

Abstract

Adoptive cell therapy (ACT) has been developed in cancer treatment by transferring/infusing immune cells into cancer patients, which are able to recognize, target, and destroy tumor cells. Recently, sipuleucel-T and genetically-modified T cells expressing chimeric antigen receptors (CAR) show a great potential to control metastatic castration-resistant prostate cancer and hematologic malignancies in clinic. This review summarized some of the major evidence-based ACT and the challenges to improve cell quality and reduce the side effects in the field. This review also provided future research directions to make sure ACT widely available in clinic.

Keywords: Adoptive cell therapy (ACT); dendritic cell-based therapy; non-specific cell therapy; specific cell therapy.

Publication types

  • Review

MeSH terms

  • Cancer Vaccines / therapeutic use*
  • Humans
  • Immunotherapy, Adoptive / trends*
  • Male
  • Neoplasms / therapy*
  • Prostatic Neoplasms, Castration-Resistant / therapy
  • T-Lymphocytes
  • Tissue Extracts / therapeutic use*

Substances

  • Cancer Vaccines
  • Tissue Extracts
  • sipuleucel-T