Synthesis of lipid-based amphiphilic block copolymer and its evaluation as nano drug carrier

Muhammad Arshad; Rehan A Pradhan; Aman Ullah

doi:10.1016/j.msec.2017.03.109

Synthesis of lipid-based amphiphilic block copolymer and its evaluation as nano drug carrier

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1:76:217-223. doi: 10.1016/j.msec.2017.03.109. Epub 2017 Mar 14.

Authors

Muhammad Arshad¹, Rehan A Pradhan¹, Aman Ullah²

Affiliations

¹ Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada.
² Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada. Electronic address: amanullah@ualberta.ca.

PMID: 28482520
DOI: 10.1016/j.msec.2017.03.109

Abstract

In current study, we report the synthesis and characterization of renewable fatty acid-based block copolymer. The block copolymer was synthesized via RAFT polymerization under microwave irradiations. Firstly, the homopolymer of N,N-dimethylacrylamide (DMA) was prepared and used as a macro-CTA to copolymerize with modified stearic acid monomer (SAM). The characterization of copolymer p-DMA-b-SAM was done by ¹H NMR, ATR-FTIR and GPC. The block copolymer was allowed to self-assemble and the entrapment of carbamazepine (CBZ) into hydrophobic core of polymeric micelles was investigated in aqueous media. A high drug entrapment efficiency (69%) was observed for block copolymer micelles. The spherical appearance of micelles in the size range of 20-70nm was determined with transmission electron microscopy (TEM). An effort was also made to investigate the in vitro release profile of CBZ from micelles. A sustained drug release rate was observed, showing complete release of drug within 70h.

Keywords: Block copolymer; Drug delivery; Fatty acids; Self-assembly.

MeSH terms

Acrylamides
Drug Carriers
Hydrophobic and Hydrophilic Interactions
Lipids / chemistry*
Micelles
Polymers

Substances

Acrylamides
Drug Carriers
Lipids
Micelles
Polymers
N,N-dimethylacrylamide