Incidental Prostate-Specific Membrane Antigen Uptake in a Peripheral Nerve Sheath Tumor

Clin Nucl Med. 2017 Jul;42(7):560-562. doi: 10.1097/RLU.0000000000001686.

Abstract

A 66-year-old man with recently diagnosed prostate cancer (Gleason score 9) was referred for Ga-prostate-specific membrane antigen (PSMA) PET/CT with prostate-specific antigen level of 7.5 μg/L. PET/CT demonstrated increased PSMA uptake (SUVmax 4.7) in a soft tissue density in the left adductor compartment. MRI and cytopathology of the biopsied soft tissue density was compatible with a peripheral nerve sheath tumor. This case illustrates that PSMA uptake can occur in a peripheral nerve sheath tumor and should be taken into consideration as a benign cause of PSMA uptake.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism*
  • Biopsy
  • Glutamate Carboxypeptidase II / metabolism*
  • Humans
  • Incidental Findings*
  • Male
  • Nerve Sheath Neoplasms / diagnostic imaging
  • Nerve Sheath Neoplasms / metabolism*
  • Nerve Sheath Neoplasms / pathology
  • Positron Emission Tomography Computed Tomography
  • Protein Transport

Substances

  • Antigens, Surface
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II