Diagnosing neuroleukemiosis: Is there a role for 18F-FDG-PET/CT?
Rev Esp Med Nucl Imagen Mol. 2017 Nov-Dec;36(6):396-398.
doi: 10.1016/j.remn.2017.02.010.
Epub 2017 May 4.
[Article in
English,
Spanish]
Affiliations
- 1 PET Unit, Department of Nuclear Medicine - IDI, Hospital Universitari de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: asabatell@bellvitgehospital.cat.
- 2 PET Unit, Department of Nuclear Medicine - IDI, Hospital Universitari de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
- 3 Hematologic Citology, Department of Pathology, Hospital Universitari de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
- 4 Department of Radiology - IDI, Hospital Universitari de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Abstract
An imaging case is presented on a patient referred to our department for an 18F-FDG-PET/CT, as a paraneoplastic syndrome was suspected due to his clinical situation. He had a history of acute myeloid leukemia (AML) treated two years earlier, with sustained complete remission to date. 18F-FDG-PET/CT findings revealed hypermetabolism in almost all nerve roots, suggesting meningeal spread, consistent with the subsequent MRI findings. Cerebrospinal fluid (CSF) findings confirmed a leptomeningeal reactivation of AML. Although not many studies have evaluated the role of 18F-FDG-PET/CT in leukemia, it is a noninvasive tool for detecting extramedullary sites of disease and a good imaging alternative for those patients on whom an MRI cannot be performed.
Keywords:
Acute myeloid leukemia; FDG; Leucemia mieloide aguda; Meningeal relapse; Neuroleucemiosis; Neuroleukemiosis; PET/CT; PET/TC; Recidiva meníngea.
Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.
MeSH terms
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Fluorodeoxyglucose F18*
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Humans
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Leukemic Infiltration / diagnostic imaging*
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Male
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Middle Aged
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Nervous System / diagnostic imaging*
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Nervous System / pathology*
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Positron Emission Tomography Computed Tomography*
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Radiopharmaceuticals*
Substances
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Radiopharmaceuticals
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Fluorodeoxyglucose F18