Determination of predictors of severity for recipient adverse reactions during platelet product transfusions

Abstract

The introduction of allogeneic cells is not a natural process, even if the transfusion is therapeutic and - when no alternative exists, as is often the case - essential. Transfusion of cellular products creates some level of danger sensed by recipients. Danger may manifest itself clinically or biologically, in which case we are dealing with recipient adverse reactions. Platelet concentrate transfusion in particular may be responsible for notable adverse reactions. Some appear to be inevitable, while others are tied to recipient factors: either health or genetic characteristics. The authors' research is specifically focused on platelet storage lesion and stress factors, and the means of controlling them to ensure greater recipient tolerance.

Keywords: Adverse reactions; Biological response modifier; Cellules endothéliales; Effets indésirables receveurs; Endothelial cells; Inflammation; Modificateurs du comportement biologique; Plaquettes; Platelets; Transfusion.