The mechanisms tumor cells utilize to evade the host's immune system

Nyanbol Kuol; Lily Stojanovska; Kulmira Nurgali; Vasso Apostolopoulos

doi:10.1016/j.maturitas.2017.04.014

The mechanisms tumor cells utilize to evade the host's immune system

Maturitas. 2017 Nov:105:8-15. doi: 10.1016/j.maturitas.2017.04.014. Epub 2017 Apr 27.

Authors

Nyanbol Kuol¹, Lily Stojanovska¹, Kulmira Nurgali¹, Vasso Apostolopoulos²

Affiliations

¹ Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne, VIC 8001, Australia.
² Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne, VIC 8001, Australia. Electronic address: Vasso.Apostolopoulos@vu.edu.au.

PMID: 28477990
DOI: 10.1016/j.maturitas.2017.04.014

Abstract

The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.

Keywords: Indoleamine-2,3-dioxygenase; Major histocompatibility complex; Programmed death-ligand 1; Siglec-9; Tumor escape.

Publication types

Review

MeSH terms

Animals
Humans
Immune Tolerance*
Neoplasms / immunology*