Mechanisms of endothelial dysfunction during aging: Predisposition to thrombosis

Mech Ageing Dev. 2017 Jun:164:91-99. doi: 10.1016/j.mad.2017.04.011. Epub 2017 May 3.

Abstract

One of the risk factors for developing cardiovascular disease (CVD) is aging. In the elderly endothelial dysfunction occurs as altered endothelial ability to regulate hemostasis, vascular tone and cell permeability. In addition, there are changes in the expression and plasma levels of important endothelial components related to endothelial-mediated modulation in hemostasis. These include alterations in the metabolism of nitric oxide and prostanoides, endothelin-1, thrombomodulin and Von Willebrand factor. These alterations potentiate the pro-coagulant status developed with aging, highlighting the endothelial role in the development of thrombosis in aging.

Keywords: Aging; Endothelial dysfunction; Thrombosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Disease Susceptibility / metabolism
  • Disease Susceptibility / pathology
  • Endothelin-1 / metabolism
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • Hemostasis*
  • Humans
  • Nitric Oxide / metabolism
  • Thrombomodulin / metabolism
  • Thrombosis / metabolism*
  • Thrombosis / pathology
  • von Willebrand Factor / metabolism

Substances

  • Endothelin-1
  • THBD protein, human
  • Thrombomodulin
  • von Willebrand Factor
  • Nitric Oxide