Primary central nervous system lymphoma as a neurosurgical problem

Dariusz Szczepanek; Ewa Wąsik-Szczepanek; Filip Stoma; Bożena Sokołowska; Tomasz Trojanowski

doi:10.1016/j.pjnns.2017.04.004

Primary central nervous system lymphoma as a neurosurgical problem

Neurol Neurochir Pol. 2017 Jul-Aug;51(4):319-323. doi: 10.1016/j.pjnns.2017.04.004. Epub 2017 Apr 19.

Authors

Dariusz Szczepanek¹, Ewa Wąsik-Szczepanek², Filip Stoma³, Bożena Sokołowska², Tomasz Trojanowski³

Affiliations

¹ Department of Neurosurgery and Paediatric Neurosurgery, Medical University in Lublin, Poland. Electronic address: dariuszszczepanek@umlub.pl.
² Department of Haematooncology and Bone Marrow Transplantation, Medical University in Lublin, Poland.
³ Department of Neurosurgery and Paediatric Neurosurgery, Medical University in Lublin, Poland.

PMID: 28476199
DOI: 10.1016/j.pjnns.2017.04.004

Abstract

Primary central nervous system lymphoma (PCNSL) comprises around 3-5% of primary central nervous system (CNS) tumours and around 1% of all non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common histological type. High effectiveness of chemo- and radiotherapy for PCNSL regrettably does not eliminate significant risks of recurrence for CNS tumours. That results in higher interest in other treatment options, including surgical procedures. PCNSL remains in the scope of interest for many specialists and neurosurgeons seem to play a more important role.

Keywords: Primary central nervous system lymphoma; Radiosurgery; Stereotactic biopsy.

Publication types

Review

MeSH terms

Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / therapeutic use
Central Nervous System Neoplasms / therapy*
Glucocorticoids / therapeutic use*
Humans
Injections, Intraventricular
Injections, Spinal
Lymphoma / therapy*
Lymphoma, Large B-Cell, Diffuse / therapy
Lymphoma, Non-Hodgkin / therapy
Neurosurgical Procedures*
Radiosurgery*
Stereotaxic Techniques

Substances

Antineoplastic Agents
Glucocorticoids