Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus

Natalya A Ortolano; Vivian Gama

doi:10.1016/j.molcel.2017.04.014

Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus

Mol Cell. 2017 May 4;66(3):301-303. doi: 10.1016/j.molcel.2017.04.014.

Authors

Natalya A Ortolano¹, Vivian Gama²

Affiliations

¹ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
² Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37240, USA. Electronic address: vivian.gama@vanderbilt.edu.

PMID: 28475865
DOI: 10.1016/j.molcel.2017.04.014

Abstract

In this issue of Molecular Cell, Benvegnù et al. (2017) report an unexpected phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to the nucleus in an age-dependent manner, revealing an intriguing mechanism that allows for an adaptive neuronal response to proteotoxic stress, often seen with aging.

Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus

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