1 Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Division of Critical Care Medicine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; Pediatric Critical Care Medicine, Departments of Pediatrics and Public Health Sciences, Penn State University College of Medicine, Hershey, PA; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA; for the Sepsis Prevalence, Outcomes, and Therapy Study.