Fractional flow reserve (FFR) is an objective physiological index utilized in coronary angiography. It expresses the blood flow in the presence of a coronary artery stenosis as a fraction of the normal blood flow and gives information regarding the functional significance of the lesion. FFR guided percutaneous coronary intervention (PCI) has been shown to be superior to angiography guided PCI in several trials and registries. In addition, it appears that the use of FFR may also be preferable from an economic perspective. Areas covered: This article will cover the physiological principles underpinning FFR, the landmark clinical trials that have established its diagnostic utility and the current recommendations for the use of the procedure in daily practice. We will also examine potential future directions for the technology and try to predict how its use will evolve in the next five years. Expert commentary: We see FFR as an essential diagnostic tool in the modern catheterization laboratory, enabling physicians to make optimal decisions regarding percutaneous coronary intervention for an individual patient. It must be stated however that FFR is an adjunctive invasive functional tool that must be used in conjunction with sensible clinical history and exam findings pertaining to the individual patient. We expect that the results of FAME3 will further establish the role of FFR in risk stratifying patients with 3 vessel disease by utilizing a functional SYNTAX score.
Keywords: Coronary artery disease; Fractional flow reserve; Ischemic heart disease.