NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors

Haematologica. 2017 Aug;102(8):e285-e288. doi: 10.3324/haematol.2016.160788. Epub 2017 May 4.

Authors

Xingguo Zhu¹, Biaoru Li², Betty S Pace^{2

3}

Affiliations

¹ Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA, USA xzhu@augusta.edu.
² Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA, USA.
³ Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Cells, Cultured
Erythroid Precursor Cells / metabolism*
Fetal Hemoglobin / genetics*
Gene Expression Regulation*
Humans
NF-E2-Related Factor 2 / metabolism
NF-E2-Related Factor 2 / physiology*
Protein Binding
Proto-Oncogene Proteins c-maf / metabolism
Transcriptional Activation
gamma-Globins / genetics*

Substances

MAF protein, human
NF-E2-Related Factor 2
Proto-Oncogene Proteins c-maf
gamma-Globins
Fetal Hemoglobin

Grants and funding