Type IV Hypersensitivity to Gold Weight Upper-Eyelid Implant: Case Report and Review of the Literature

Ocul Immunol Inflamm. 2018;26(6):910-914. doi: 10.1080/09273948.2017.1311922. Epub 2017 May 4.

Abstract

Purpose: Complications associated with gold-weight insertion for lagophthalmos are uncommon, recent reports have provided evidence to suggest that type IV hypersensitivity to gold can cause a persistent inflammatory reaction.

Methods: We present a case of a 46-year-old man who experienced persistent post-operative inflammation, and summarize previously documented cases. This patient underwent uncomplicated insertion of an upper eyelid gold weight for right-sided facial nerve palsy. He had no allergies or implanted metalwork. Post-operatively erythema was noted at seven-weeks and did not resolve. The weight was removed after six-months.

Results: The histopathological findings were in keeping with type IV hypersensitivity and similar to previous cases.

Conclusions: Although infrequent, this complication has poor outcomes. The definitive management is removal of the weight. Information regarding implanted gold, and previous reactions should be elicited pre-operatively. Type IV hypersensitivity should be considered in patients with persistent inflammation that do not respond to antibiotic or steroid therapy.

Keywords: Gold weights; inflammation; lagophthalmos; persistent erythema; type IV hypersensitivity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Blepharoplasty / adverse effects*
  • Device Removal / methods*
  • Eyelid Diseases / diagnosis
  • Eyelid Diseases / surgery*
  • Eyelids / diagnostic imaging
  • Eyelids / surgery*
  • Gold / adverse effects*
  • Humans
  • Hypersensitivity, Delayed / chemically induced*
  • Hypersensitivity, Delayed / diagnosis
  • Hypersensitivity, Delayed / surgery
  • Male
  • Middle Aged
  • Postoperative Complications / chemically induced*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / surgery
  • Prostheses and Implants / adverse effects*
  • Reoperation

Substances

  • Gold