Abstract
COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.
MeSH terms
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8,11,14-Eicosatrienoic Acid / analogs & derivatives*
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8,11,14-Eicosatrienoic Acid / chemical synthesis
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8,11,14-Eicosatrienoic Acid / chemistry
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8,11,14-Eicosatrienoic Acid / metabolism
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Cyclooxygenase 2 / chemistry
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Cyclooxygenase 2 / metabolism*
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Molecular Structure
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Stereoisomerism
Substances
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15-hydroxy-8,9-epoxyeicosatrienoic acid
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11-hydroxy-8,9-epoxyeicosatrienoic acid
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8,9-epoxyeicosatrienoic acid
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Cyclooxygenase 2
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8,11,14-Eicosatrienoic Acid