Aversive olfactory associative memory loses odor specificity over time

Abstract

Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder.

Keywords: Aversive associative memory; Drosophila melanogaster; Generalization; Long-term memory; Olfaction; PTSD; Post-traumatic stress disorder.