Thielavins W-Z₇, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

Zhuang Han; Yong-Xin Li; Ling-Li Liu; Liang Lu; Xian-Rong Guo; Xi-Xiang Zhang; Xiao-Yong Zhang; Shu-Hua Qi; Ying Xu; Pei-Yuan Qian

doi:10.3390/md15050128

Thielavins W-Z₇, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

Mar Drugs. 2017 Apr 29;15(5):128. doi: 10.3390/md15050128.

Authors

Zhuang Han^{1

2}, Yong-Xin Li³, Ling-Li Liu⁴, Liang Lu⁵, Xian-Rong Guo⁶, Xi-Xiang Zhang⁷, Xiao-Yong Zhang⁸, Shu-Hua Qi⁹, Ying Xu^{10

11}, Pei-Yuan Qian¹⁰

Affiliations

¹ Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, 28 Luhuitou Road, Sanya 572000, China. zhuanghan@idsse.ac.cn.
² Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. zhuanghan@idsse.ac.cn.
³ Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. liyongxin@connect.ust.hk.
⁴ Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. leonie@nwsuaf.edu.cn.
⁵ Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. luliangust@163.com.
⁶ Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. xianrong.guo@kaust.edu.sa.
⁷ Physical Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. xixiang.zhang@kaust.edu.sa.
⁸ Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. zhangxiaoyong@scsio.ac.cn.
⁹ Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. shuhuaqi@scsio.ac.cn.
¹⁰ Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. boxuying@szu.edu.cn.
¹¹ College of Life Science, Shenzhen University, 3688 Nanhai Ave, Shenzhen 518060, China. boxuying@szu.edu.cn.

Abstract

Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC₅₀ values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.

Keywords: Balanus (=Amphibalanus) amphitrite; Marine-derived fungus; Thielavia sp.; antifouling; thielavins.

MeSH terms

Animals
Aquatic Organisms / chemistry*
Biofouling / prevention & control*
Depsides / chemistry*
Depsides / pharmacology*
Fungi / chemistry*
Hydroxybenzoates / chemistry*
Hydroxybenzoates / pharmacology*
Sordariales / chemistry*
Thoracica / drug effects

Substances

Depsides
Hydroxybenzoates