Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B

J Nat Prod. 2017 May 26;80(5):1235-1240. doi: 10.1021/acs.jnatprod.7b00183. Epub 2017 May 3.

Abstract

The structure of the fungal phytotoxins known as the phyllostictines has been revised to a series of bicyclic 3-methylene tetramic acids. Genome sequencing of the producing organism Phyllostica cirsii has revealed a biosynthetic gene cluster responsible for the biosynthesis of the phyllostictines, and targeted knockout experiments have proven the link and produced an intermediate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Fungi / chemistry*
  • Heterocyclic Compounds, 3-Ring / chemistry
  • Heterocyclic Compounds, 3-Ring / metabolism*
  • Molecular Structure
  • Multigene Family / genetics
  • Mycotoxins / chemistry
  • Mycotoxins / isolation & purification*
  • Mycotoxins / pharmacology*
  • Pyrrolidinones / chemistry*

Substances

  • Heterocyclic Compounds, 3-Ring
  • Mycotoxins
  • Pyrrolidinones
  • phyllostictine A
  • phyllostictine B
  • tetramic acid