Abstract
The structure of the fungal phytotoxins known as the phyllostictines has been revised to a series of bicyclic 3-methylene tetramic acids. Genome sequencing of the producing organism Phyllostica cirsii has revealed a biosynthetic gene cluster responsible for the biosynthesis of the phyllostictines, and targeted knockout experiments have proven the link and produced an intermediate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Fungi / chemistry*
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / metabolism*
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Molecular Structure
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Multigene Family / genetics
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Mycotoxins / chemistry
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Mycotoxins / isolation & purification*
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Mycotoxins / pharmacology*
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Pyrrolidinones / chemistry*
Substances
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Heterocyclic Compounds, 3-Ring
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Mycotoxins
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Pyrrolidinones
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phyllostictine A
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phyllostictine B
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tetramic acid