Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions

Sami Al-Battat; Margaret L Rand; Vanessa Bouskill; Wendy Lau; Victor S Blanchette; Walter H A Kahr; Georges-Etienne Rivard; Manuel D Carcao

doi:10.1111/bjh.14623

Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions

Br J Haematol. 2018 May;181(3):410-413. doi: 10.1111/bjh.14623. Epub 2017 May 3.

Authors

Sami Al-Battat^{1

2}, Margaret L Rand^{1

2

3

4}, Vanessa Bouskill⁵, Wendy Lau⁶, Victor S Blanchette^{1

2}, Walter H A Kahr^{1

2

7

8}, Georges-Etienne Rivard⁹, Manuel D Carcao^{1

2

10}

Affiliations

¹ Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
² Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
³ Departments of Laboratory Medicine & Pathobiology, Biochemistry and Paediatrics, University of Toronto, Toronto, ON, Canada.
⁴ Physiology and Experimental Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
⁵ Department of Nursing, The Hospital for Sick Children, Toronto, ON, Canada.
⁶ Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
⁷ Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
⁸ Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
⁹ Division of Haematology/Oncology, Department of Paediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
¹⁰ Child Health Evaluative Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

PMID: 28466602
DOI: 10.1111/bjh.14623

No abstract available

Keywords: Glanzmann thrombasthenia; Platelet Function Analyser; paediatric haemostasis; platelet function; platelet transfusions.

Publication types

Letter

MeSH terms

Adolescent
Blood Platelets / metabolism*
Blood Platelets / pathology
Child
Child, Preschool
Female
Humans
Male
Platelet Function Tests
Platelet Transfusion*
Thrombasthenia / blood*
Thrombasthenia / genetics
Thrombasthenia / pathology
Thrombasthenia / therapy*