Flex-nucleoside analogues - Novel therapeutics against filoviruses

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2800-2802. doi: 10.1016/j.bmcl.2017.04.069. Epub 2017 Apr 22.

Abstract

Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC50=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC50 of 7μM.

Keywords: Antiviral; Ebola; Filovirus; Fleximers; Nucleoside.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Dose-Response Relationship, Drug
  • Ebolavirus / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nucleosides / chemical synthesis
  • Nucleosides / chemistry
  • Nucleosides / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Nucleosides