GPR55 and the regulation of glucose homeostasis

Eva Tudurí; Miguel López; Carlos Diéguez; Angel Nadal; Ruben Nogueiras

doi:10.1016/j.biocel.2017.04.010

GPR55 and the regulation of glucose homeostasis

Int J Biochem Cell Biol. 2017 Jul:88:204-207. doi: 10.1016/j.biocel.2017.04.010. Epub 2017 Apr 27.

Authors

Eva Tudurí¹, Miguel López², Carlos Diéguez², Angel Nadal³, Ruben Nogueiras⁴

Affiliations

¹ Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address: tuduri.eva@gmail.com.
² Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.
³ Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández, Elche, Spain.
⁴ Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address: ruben.nogueiras@usc.es.

PMID: 28457969
DOI: 10.1016/j.biocel.2017.04.010

Abstract

Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over-activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers potential therapeutic benefits on those diseases. GPR55, the receptor for L-α-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ligands, is distributed at the central and peripheral level and it is involved in several physiological processes. This review summarizes the localization and role of GPR55 in tissues that are crucial for the regulation of glucose metabolism, and provides an update on its contribution in obesity and insulin resistance. Finally, the therapeutic potential of targeting the GPR55 receptor is also discussed.

Keywords: Endocannabinoids; Insulin; Islets; Obesity.

Publication types

Review

MeSH terms

Animals
Gene Expression Regulation
Glucose / metabolism*
Homeostasis*
Humans
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / metabolism*

Substances

Receptors, G-Protein-Coupled
Glucose