TMEM230 in Parkinson's disease

Neurobiol Aging. 2017 Aug:56:212.e1-212.e3. doi: 10.1016/j.neurobiolaging.2017.03.014. Epub 2017 Mar 16.

Abstract

A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, age at onset, or cerebrospinal fluid α-synuclein levels.

Keywords: GWAS; Parkinson; TMEM230; WES.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • Datasets as Topic
  • Genetic Predisposition to Disease / genetics
  • Genetic Variation / genetics*
  • Genome-Wide Association Study*
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Chaperones / genetics
  • Parkinson Disease / cerebrospinal fluid
  • Parkinson Disease / genetics*
  • alpha-Synuclein / cerebrospinal fluid

Substances

  • DNAJC13 protein, human
  • Membrane Proteins
  • Molecular Chaperones
  • TMEM230 protein, human
  • alpha-Synuclein