Rhadinoviral interferon regulatory factor homologues

Biol Chem. 2017 Jul 26;398(8):857-870. doi: 10.1515/hsz-2017-0111.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.

Keywords: KSHV; antiviral mechanisms; cellular homologues; rhadinovirus; viral interferon regulatory factor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Herpesvirus 8, Human* / genetics
  • Herpesvirus 8, Human* / metabolism
  • Humans
  • Interferon Regulatory Factors* / genetics
  • Interferon Regulatory Factors* / metabolism
  • Sequence Homology, Nucleic Acid*
  • Viral Proteins* / genetics
  • Viral Proteins* / metabolism

Substances

  • Interferon Regulatory Factors
  • Viral Proteins
  • viral interferon regulatory factors