The influence of early psychosocial intervention on the long-term clinical outcomes of people suffering from schizophrenia

Psychiatr Pol. 2017 Feb 26;51(1):45-61. doi: 10.12740/PP/61903. Epub 2017 Feb 26.
[Article in English, Polish]

Abstract

Objectives: To compare the treatment outcomes of DSM-IV-TR schizophrenia patients in either a Community Treatment Program or an Individual Treatment Program (CTP vs. ITP). The assessment was made after the first hospitalization, and then after three and twelve years.

Methods: Participants were randomly assigned to CTP (experimental) and ITP (traditional) group, with 40 people in each group. 67 people (84%) participated in all three assessments. The socio-demographic and clinical indicators were the same for both groups. In the first three years only the CTP group participated in day-care treatment, patient and family psychoeducation and community treatment. Later, both groups received this treatment. The following tools were used: Anamnestic and Catamnestic Questionnaire, the GAF scale, the BPRS LA and Lehman's Quality of Life Interview.

Results: It was only after twelve years that there was a significant beneficial improvement in the mean GAF score in the CTP group (p = 0.036), which was comparable with the results obtained by Watt and Shepherd for the course of the illness in favorable remission cases (p = 0.038). The difference in the number of relapses was also significantly in favor of the CTP group only after 12 years (p = 0.045), as was the difference in the number of rehospitalizations (p = 0.013). The general severity of symptoms was found to be significantly lower for the CPT group after 3 (p = 0.008) and 12 years (p = 0.030), whereas it was significantly lower in the case of positive syndrome only after 3 years (p = 0.044).

Conclusions: 1. A greater number of favorable differences were identified for the CTP group at the twelve-year point than at the conclusion of the experiment. 2. The three-year delay in introducing psycho-social treatment was associated with a poorer long-term outcome for the clinical course of schizophrenia.

Keywords: early psychosocial interwention; long-term outcomes; schizophrenia.

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Cognitive Behavioral Therapy / methods*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Neuropsychological Tests
  • Precision Medicine / methods*
  • Psychotherapy, Group / methods*
  • Schizophrenia / drug therapy
  • Schizophrenia / therapy*
  • Schizophrenic Psychology
  • Single-Blind Method
  • Young Adult

Substances

  • Antipsychotic Agents