Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

Drug Discov Today. 2017 Sep;22(9):1421-1429. doi: 10.1016/j.drudis.2017.04.008. Epub 2017 Apr 26.

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Ferric Compounds / therapeutic use*
  • Genetic Therapy
  • Humans
  • Hyperthermia, Induced
  • Magnetic Phenomena
  • Metal Nanoparticles / therapeutic use*
  • Neoplasms / diagnosis*
  • Neoplasms / therapy*
  • Phototherapy
  • Theranostic Nanomedicine

Substances

  • Ferric Compounds
  • ferric oxide