Antibodies to Shiga toxins in Brazilian cattle

Bruno B Yamamoto; Daniela Luz; Patrícia A E Abreu; Tatiana B Gotti; Silvio A Vasconcellos; Roxane M F Piazza; Denise S P Q Horton

doi:10.1016/j.toxicon.2017.04.014

Antibodies to Shiga toxins in Brazilian cattle

Toxicon. 2017 Jul:133:58-62. doi: 10.1016/j.toxicon.2017.04.014. Epub 2017 Apr 25.

Authors

Bruno B Yamamoto¹, Daniela Luz¹, Patrícia A E Abreu¹, Tatiana B Gotti¹, Silvio A Vasconcellos², Roxane M F Piazza³, Denise S P Q Horton¹

Affiliations

¹ Laboratório de Bacteriologia, Instituto Butantan, São Paulo, Brazil.
² Laboratório de Zoonoses Bacterianas, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
³ Laboratório de Bacteriologia, Instituto Butantan, São Paulo, Brazil. Electronic address: roxane@butantan.gov.br.

PMID: 28454739
DOI: 10.1016/j.toxicon.2017.04.014

Abstract

Cattle are considered a reservoir of Shiga toxin-producing Escherichia coli (STEC). There is no information about the presence of antibodies against Shiga toxins in Brazilian bovine serum. Using ELISA, all sera tested showed antibodies against the two main STEC virulence factors; Stx1 and Stx2. Neutralizing antibodies against Stx1 and/or Stx2 were detected in all but one serum. In conclusion, our results indicated that these animals had been exposed to STEC producing both toxins.

Keywords: Antibodies; Cattle; Escherichia coli; STEC; Shiga toxin; Stx1; Stx2.

MeSH terms

Animals
Antibodies, Bacterial / blood*
Brazil / epidemiology
Cattle
Cattle Diseases / immunology*
Cattle Diseases / microbiology*
Disease Reservoirs / veterinary
Escherichia coli Infections / immunology
Escherichia coli Infections / microbiology
Escherichia coli Infections / veterinary*
Serotyping
Shiga Toxins / immunology*
Shiga-Toxigenic Escherichia coli / immunology*

Substances

Antibodies, Bacterial
Shiga Toxins