Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging

Ilaria Monaco; Francesca Arena; Stefania Biffi; Erica Locatelli; Barbara Bortot; Francesca La Cava; Giada Maria Marini; Giovanni Maria Severini; Enzo Terreno; Mauro Comes Franchini

doi:10.1021/acs.bioconjchem.7b00076

Synthesis of Lipophilic Core-Shell Fe₃O₄@SiO₂@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging

Bioconjug Chem. 2017 May 17;28(5):1382-1390. doi: 10.1021/acs.bioconjchem.7b00076. Epub 2017 May 3.

Affiliations

¹ Department of Industrial Chemistry "Toso Montanari", University of Bologna , Viale del Risorgimento 4, Bologna 40136, Italy.
² Molecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Healthy Sciences, University of Torino , Via Nizza 52, Torino 10126, Italy.
³ Institute for Maternal and Child Health- IRCCS "Burlo Garofolo" , Via dell'Istria 65/1, Trieste 34137, Italy.

PMID: 28453929
DOI: 10.1021/acs.bioconjchem.7b00076

Abstract

In this work, iron/silica/gold core-shell nanoparticles (Fe₃O₄@SiO₂@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Proliferation / drug effects
Female
Ferric Compounds / chemistry*
Folic Acid / chemistry
Gold / chemistry*
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods*
Magnetite Nanoparticles / administration & dosage*
Magnetite Nanoparticles / chemistry
Mice
Mice, Inbred BALB C
Mice, Nude
Micelles
Multimodal Imaging / methods
Ovarian Neoplasms / metabolism
Ovarian Neoplasms / pathology*
Photoacoustic Techniques / methods*
Polymers / chemistry*
Silicon Dioxide / chemistry*
Tumor Cells, Cultured
Xenograft Model Antitumor Assays

Substances

Ferric Compounds
Magnetite Nanoparticles
Micelles
Polymers
ferric oxide
Gold
Silicon Dioxide
Folic Acid