In article presented results of the study of basic levels of regulatory cytokines in patients with various forms of Epstein-Barr virus (EBV) infection. Analysis of the dynamics of cytokine profile in patients with EBV infection revealed the opposite changes studied synthesis of proinflammatory and anti-inflammatory cytokines, which was the basis for the establishment of the four types of immune response. The findings confirm the existence of cytokine imbalance with EBV infection. The established types of immune responses indicate inadequate cell humoral reactivity in a long persistence of EBV, which manifests a tendency to suppression of cell-mediated and humoral immune response enhancement mechanisms and displayed in the clinical and biochemical manifestations of the disease, and also leads to prolonged undulating course.