Introduction: Platelets are known for their key role in hemostasis and controlling the bleeding after injury. The fact that platelets secrete growth factors and active metabolites means that their applied use can have a positive influence in clinical situations requiring rapid healing and tissue regeneration.
Objectives: Platelet Rich Plasma has been described as a promising but unproven therapy.
Materials and methods: Whole blood was undergoing one stage of centrifugation. The whole blood was then separated into three layers. One ml of the lowest layer of plasma was administered to the patient's nose.
Results: After the third and finally the fourth therapy, 4 of 5 patients said that "their smell came back", while the remaining one patient said that he could smell a lot but not everything.
Conclusion: Based on our results, platelet rich plasma administration to the olfactory region could be a promising, last chance therapy for complete anosmia.
Keywords: anosmia; platelet rich plasma.