Harnessing macrophage plasticity for tissue regeneration

Tim D Smith; Raji R Nagalla; Esther Y Chen; Wendy F Liu

doi:10.1016/j.addr.2017.04.012

Harnessing macrophage plasticity for tissue regeneration

Adv Drug Deliv Rev. 2017 May 15:114:193-205. doi: 10.1016/j.addr.2017.04.012. Epub 2017 Apr 25.

Authors

Tim D Smith¹, Raji R Nagalla¹, Esther Y Chen², Wendy F Liu³

Affiliations

¹ Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States.
² Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States.
³ Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States. Electronic address: wendy.liu@uci.edu.

PMID: 28449872
DOI: 10.1016/j.addr.2017.04.012

Abstract

Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention.

Keywords: Biomaterials; Immunomodulation; Macrophage polarization; Nanoparticles; Wound healing.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / therapeutic use
Humans
Inflammation / immunology
Macrophages / drug effects*
Macrophages / immunology*
Macrophages / transplantation
Regeneration / drug effects
Regeneration / immunology*
Regenerative Medicine / methods*
Wound Healing / drug effects
Wound Healing / immunology

Substances

Biocompatible Materials

Grants and funding

T32 GM008620/GM/NIGMS NIH HHS/United States