Cytomegalovirus Anterior Uveitis Following Topical Cyclosporine A

Ocul Immunol Inflamm. 2018;26(1):90-93. doi: 10.1080/09273948.2017.1306083. Epub 2017 Apr 27.

Abstract

Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals and may manifest as Posner-Schlossman syndrome or Fuchs uveitis syndrome. The condition may first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, or the use of topical prostaglandin analogues for the treatment of glaucoma. We report the first case of a non-human immunodeficiency virus-infected individual who presented with CMV anterior uveitis after the use of topical cyclosporine A 0.05% ophthalmic emulsion for the treatment of symptomatic dry eyes.

Publication types

  • Case Reports

MeSH terms

  • Administration, Ophthalmic
  • Aged
  • Antiviral Agents / therapeutic use
  • Aqueous Humor / virology
  • Cyclosporine / adverse effects*
  • Cytomegalovirus / genetics
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / etiology*
  • DNA, Viral / genetics
  • Dry Eye Syndromes / drug therapy
  • Emulsions
  • Eye Infections, Viral / diagnosis
  • Eye Infections, Viral / drug therapy
  • Eye Infections, Viral / etiology*
  • Female
  • Ganciclovir / analogs & derivatives
  • Ganciclovir / therapeutic use
  • Gene Dosage
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Real-Time Polymerase Chain Reaction
  • Uveitis, Anterior / diagnosis
  • Uveitis, Anterior / drug therapy
  • Uveitis, Anterior / etiology*
  • Valganciclovir

Substances

  • Antiviral Agents
  • DNA, Viral
  • Emulsions
  • Immunosuppressive Agents
  • Cyclosporine
  • Valganciclovir
  • Ganciclovir