An Approach to the Core of Lactonamycin

Philip J Parsons; Daniel R Jones; Lee J Walsh; Lewis A T Allen; Ada Onwubiko; Lewis Preece; Johnathan Board; Andrew J P White

doi:10.1021/acs.orglett.7b00902

An Approach to the Core of Lactonamycin

Org Lett. 2017 May 19;19(10):2533-2535. doi: 10.1021/acs.orglett.7b00902. Epub 2017 Apr 26.

Authors

Philip J Parsons¹, Daniel R Jones¹, Lee J Walsh¹, Lewis A T Allen¹, Ada Onwubiko¹, Lewis Preece², Johnathan Board², Andrew J P White¹

Affiliations

¹ Department of Chemistry, Imperial College London , South Kensington, London SW7 2AZ, U.K.
² Department of Chemistry, University of Sussex , Falmer, Brighton BN1 9RH, U.K.

PMID: 28445072
DOI: 10.1021/acs.orglett.7b00902

Abstract

A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.

Publication types

Research Support, Non-U.S. Gov't