Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients

Br J Haematol. 2018 May;181(4):552-554. doi: 10.1111/bjh.14663. Epub 2017 Apr 26.

Authors

Pradeep K Dagur¹, J Philip McCoy¹, James Nichols¹, Laura Mendelsohn¹, Catherine Seamon¹, Gregory J Kato², Eduard J van Beers³

Affiliations

¹ Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
² Division of Hematology-Oncology and Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
³ Van Creveldkliniek, Centre for Benign Haematology, University Medical Centre Utrecht, Utrecht, the Netherlands.

No abstract available

Keywords: inflammation; iron metabolism; monocytes; sickle cell disease; toll-like receptor 4.

Publication types

Letter
Research Support, N.I.H., Intramural

MeSH terms

Anemia, Sickle Cell / metabolism*
Anemia, Sickle Cell / pathology
Humans
Inflammation / chemically induced
Inflammation / metabolism
Inflammation / pathology
Iron Chelating Agents / pharmacology*
Lipopolysaccharides / toxicity
Monocytes / metabolism*
Monocytes / pathology
Toll-Like Receptor 4 / metabolism*

Substances

Iron Chelating Agents
Lipopolysaccharides
TLR4 protein, human
Toll-Like Receptor 4

Grants and funding