A biosensor based on self-clickable AIEgen: a signal amplification strategy for ultrasensitive immunoassays

Chem Commun (Camb). 2017 May 9;53(38):5287-5290. doi: 10.1039/c7cc01093a.

Abstract

A signal amplified fluorogenic ELISA based on self-clickable fluorogens with aggregation-induced emission characteristics (AIEgen) as a substrate was developed for ultrasensitive immunoassay.

MeSH terms

  • Alkaline Phosphatase / metabolism
  • Animals
  • Ascorbic Acid / chemistry
  • Biosensing Techniques / methods*
  • Copper / chemistry
  • Fluorescent Dyes / chemistry
  • Immunoassay / methods*
  • Immunoglobulin G / analysis
  • Polymers / chemistry
  • Rabbits
  • Stilbenes / chemistry
  • Substrate Specificity

Substances

  • Fluorescent Dyes
  • Immunoglobulin G
  • Polymers
  • Stilbenes
  • tetraphenylethylene
  • Copper
  • Alkaline Phosphatase
  • Ascorbic Acid