Data on the mRNA expression by in situ hybridization of Wnt signaling pathway members in the mouse uterus

Jyoti Goad; Yi-An Ko; Shafiq M Syed; Yazmin J Crossingham; Pradeep S Tanwar

doi:10.1016/j.dib.2017.03.047

Data on the mRNA expression by in situ hybridization of Wnt signaling pathway members in the mouse uterus

Data Brief. 2017 Apr 8:12:208-212. doi: 10.1016/j.dib.2017.03.047. eCollection 2017 Jun.

Authors

Jyoti Goad¹, Yi-An Ko¹, Shafiq M Syed¹, Yazmin J Crossingham¹, Pradeep S Tanwar¹

Affiliation

¹ School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales 2308, Australia.

Abstract

Wnt signaling plays an important role in uterine organogenesis and oncogenesis. Our mRNA expression data documents the expression of various Wnt pathway members during the key stages of uterine epithelial gland development. Our data illustrates the expression of Wnt signaling inhibitors (Axin2, Sfrp2, Sfrp4, Dkk1 and Dkk3) in mice uteri at postnatal day 6 (PND 6) and day 15 (PND 15). They also describe the expression pattern of the Wnt ligands (Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt5b, Wnt7b, Wnt8a, Wnt8b, Wnt9a, Wnt9b, Wnt10a and Wnt10b) in mice uteri with or without progesterone treatment. Detailed interpretation and discussion of these data is presented in the research article entitled "Differential Wnt signaling activity limits epithelial gland development to the anti-mesometrial side of the mouse uterus" [1].

Keywords: Endometrium; Glands; Uterus; Wnt; β-catenin.