A photoconversion model for full spectral programming and multiplexing of optogenetic systems

Mol Syst Biol. 2017 Apr 24;13(4):926. doi: 10.15252/msb.20167456.

Abstract

Optogenetics combines externally applied light signals and genetically engineered photoreceptors to control cellular processes with unmatched precision. Here, we develop a mathematical model of wavelength- and intensity-dependent photoconversion, signaling, and output gene expression for our two previously engineered light-sensing Escherichia coli two-component systems. To parameterize the model, we develop a simple set of spectral and dynamical calibration experiments using our recent open-source "Light Plate Apparatus" device. In principle, the parameterized model should predict the gene expression response to any time-varying signal from any mixture of light sources with known spectra. We validate this capability experimentally using a suite of challenging light sources and signals very different from those used during the parameterization process. Furthermore, we use the model to compensate for significant spectral cross-reactivity inherent to the two sensors in order to develop a new method for programming two simultaneous and independent gene expression signals within the same cell. Our optogenetic multiplexing method will enable powerful new interrogations of how metabolic, signaling, and decision-making pathways integrate multiple input signals.

Keywords: optogenetics; predictive modeling; spectral multiplexing; synthetic biology; two‐component systems.

MeSH terms

  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Genetic Engineering
  • Light Signal Transduction
  • Models, Genetic
  • Models, Theoretical
  • Optogenetics / methods*
  • Photoreceptors, Microbial / genetics
  • Photoreceptors, Microbial / metabolism*

Substances

  • Escherichia coli Proteins
  • Photoreceptors, Microbial