Atypical Small Acinar Proliferation and High-grade Prostatic Intraepithelial Neoplasia in the Era of Multiparametric Magnetic Resonance Imaging: A Contemporary Review

Todd G Manning; Ernest Cheung; Marlon Perera; Daniel Christidis; Jonathan S O'Brien; Catherine Mitchell; Damien M Bolton; Nathan Lawrentschuk

doi:10.1016/j.urology.2017.04.021

Atypical Small Acinar Proliferation and High-grade Prostatic Intraepithelial Neoplasia in the Era of Multiparametric Magnetic Resonance Imaging: A Contemporary Review

Urology. 2017 Sep:107:5-10. doi: 10.1016/j.urology.2017.04.021. Epub 2017 Apr 21.

Authors

Todd G Manning¹, Ernest Cheung², Marlon Perera², Daniel Christidis², Jonathan S O'Brien², Catherine Mitchell³, Damien M Bolton⁴, Nathan Lawrentschuk⁵

Affiliations

¹ University of Melbourne, Department of Surgery, Austin Health, Melbourne, Australia; The Young Urology Researchers Organisation (YURO), Melbourne, Australia. Electronic address: doctor.tmanning@gmail.com.
² University of Melbourne, Department of Surgery, Austin Health, Melbourne, Australia; The Young Urology Researchers Organisation (YURO), Melbourne, Australia.
³ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.
⁴ University of Melbourne, Department of Surgery, Austin Health, Melbourne, Australia.
⁵ University of Melbourne, Department of Surgery, Austin Health, Melbourne, Australia; Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Australia.

PMID: 28438627
DOI: 10.1016/j.urology.2017.04.021

Abstract

Multiparametric magnetic resonance imaging (mpMRI) has added to the armamentarium for the diagnosis and surveillance for organ-confined prostate cancer. Atypical small acinar proliferation and high-grade prostatic intraepithelial neoplasia (HGPIN) are premalignant prostatic lesions. The management of such lesions remains contentious, and the addition of mpMRI introduces further uncertainty, given its ability to pick up indolent lesions and its use in targeted biopsy. We aimed to perform a comprehensive review of current evidence regarding atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and mpMRI to ascertain a consensus for a current management algorithm.

Publication types

Review

MeSH terms

Algorithms*
Cell Proliferation
Humans
Image-Guided Biopsy / methods*
Magnetic Resonance Imaging / methods*
Male
Neoplasm Grading / methods*
Prostate / pathology*
Prostatic Intraepithelial Neoplasia / pathology*
Prostatic Neoplasms / pathology