Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy/PDT Treatment of Hepatocellular Carcinoma

Da Zhang; Aixian Zheng; Juan Li; Ming Wu; Zhixiong Cai; Lingjie Wu; Zuwu Wei; Huanghao Yang; Xiaolong Liu; Jingfeng Liu

doi:10.1002/advs.201600460

Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy/PDT Treatment of Hepatocellular Carcinoma

Adv Sci (Weinh). 2017 Jan 24;4(4):1600460. doi: 10.1002/advs.201600460. eCollection 2017 Apr.

Authors

Da Zhang^{1

2}, Aixian Zheng^{1

2}, Juan Li³, Ming Wu^{1

2}, Zhixiong Cai^{1

2}, Lingjie Wu^{1

2}, Zuwu Wei^{1

2}, Huanghao Yang³, Xiaolong Liu^{1

2}, Jingfeng Liu^{1

2

4}

Affiliations

¹ The Liver Center of Fujian Province Fujian Medical University Fuzhou 350025 P. R. China.
² The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou 350025 P. R. China.
³ The Key Lab of Analysis and Detection Technology for Food Safety of the MOE Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety College of Chemistry Fuzhou University Fuzhou 350002 P. R. China.
⁴ Liver Disease Center The First Affiliated Hospital of Fujian Medical University Fuzhou 350005 P. R. China.

Abstract

Smart self-assembled "Turn-ON" DNA hybrids are employed, which could respond to tumor microenvironment stimuli for cancer cell specific real-time fluorescence imaging, tumor-specific synergistic photodynamic therapy and chemotherapy in hepatocellular carcinoma.

Keywords: aptamer; chemotherapy; hepatocellular carcinoma; photodynamic therapy; stimuli‐responsive.