Therapeutic strategies in Sickle Cell Anemia: The past present and future

Abstract

Sickle Cell Anemia (SCA) was one of the first hemoglobinopathies to be discovered. It is distinguished by the mutation-induced expression of a sickle cell variant of hemoglobin (HbS) that triggers erythrocytes to take a characteristic sickled conformation. The complex physiopathology of the disease and its associated clinical complications has initiated multi-disciplinary research within its field. This review attempts to lay emphasis on the evolution, current standpoint and future scope of therapeutic strategies in SCA.

Keywords: Hemoglobinopathies; Sickle Cell Anemia; Sickle Cell Research; Sickle Cell Therapeutics.