The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers

Amyloid. 2017 Mar;24(sup1):83-84. doi: 10.1080/13506129.2016.1278362.

Authors

N P Gonçalves^{1

2}, D Martins^{1

2}, M J Saraiva^{1

2}

Affiliations

¹ a Instituto de Inovação e Investigação em Saúde (I3S), Universidade do Porto , Portugal and.
² b IBMC Unidade de Neurobiologia Molecular, Universidade do Porto , Portugal.

PMID: 28434291
DOI: 10.1080/13506129.2016.1278362

No abstract available

Keywords: Animal models; Protochaderin 10; disease markers; nerve.

MeSH terms

Amyloid / genetics
Amyloid / metabolism
Amyloid Neuropathies, Familial / genetics*
Amyloid Neuropathies, Familial / metabolism
Amyloid Neuropathies, Familial / pathology
Animals
Biomarkers / metabolism
Brain / metabolism*
Brain / pathology
Cadherins / genetics*
Cadherins / metabolism
Disease Models, Animal
Exome Sequencing
Gene Expression Regulation
Heat Shock Transcription Factors / genetics
Heat Shock Transcription Factors / metabolism
Humans
Immunohistochemistry
Mice
Mice, Transgenic
Microarray Analysis
Mutation
Peripheral Nerves / metabolism*
Peripheral Nerves / pathology
Prealbumin / genetics*
Prealbumin / metabolism
Protocadherins
Schwann Cells / metabolism
Schwann Cells / pathology

Substances

Amyloid
Biomarkers
Cadherins
Heat Shock Transcription Factors
Hsf1 protein, mouse
Pcdh10 protein, mouse
Prealbumin
Protocadherins

Supplementary concepts

Amyloidosis, Hereditary, Transthyretin-Related