ESAS and FACT-B in eribulin-treated metastatic breast cancer patients: a multicenter, prospective and observational study

Future Oncol. 2017 Jul;13(17):1517-1525. doi: 10.2217/fon-2017-0062. Epub 2017 Apr 21.

Abstract

Aim: Quality of life (QoL) is a critical issue for women with metastatic breast cancer (MBC). Eribulin mesylate represents a novel and active drug for pretreated MBC. Regretfully, few data exploring health-related (HR) QoL are available in unselected populations.

Patients & methods: A multicenter prospective observational study was conducted in 50 MBC patients treated with eribulin mesylate, in order to evaluate HRQoL and patients' well-being by using the Edmonton symptoms assessment scale (ESAS) and Functional Assessment of Cancer Therapy-Breast questionnaires.

Results: A significant ESAS score improvement was observed with a 10% median decrease. No differences were revealed for the QoL scores.

Conclusion: The analysis of ESAS and Functional Assessment of Cancer Therapy scores showed that eribulin mesylate contributes to preserve QoL in MBC patients.

Keywords: Edmonton symptoms assessment scale; eribulin mesylate; metastatic breast cancer; quality of life.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / pathology
  • Female
  • Furans / administration & dosage*
  • Furans / adverse effects
  • Humans
  • Ketones / administration & dosage*
  • Ketones / adverse effects
  • Middle Aged
  • Neoplasm Metastasis
  • Prospective Studies
  • Quality of Life
  • Surveys and Questionnaires
  • Treatment Outcome

Substances

  • Furans
  • Ketones
  • eribulin