Magnetic Resonance Imaging of Tumors with the Use of Iron Oxide Magnetic Nanoparticles as a Contrast Agent

A S Semkina; M A Abakumov; N F Grinenko; A A Lipengolts; N V Nukolova; V P Chekhonin

doi:10.1007/s10517-017-3718-x

Magnetic Resonance Imaging of Tumors with the Use of Iron Oxide Magnetic Nanoparticles as a Contrast Agent

Bull Exp Biol Med. 2017 Apr;162(6):808-811. doi: 10.1007/s10517-017-3718-x. Epub 2017 Apr 21.

Authors

A S Semkina¹, M A Abakumov^{2

3}, N F Grinenko⁴, A A Lipengolts^{5

6}, N V Nukolova⁴, V P Chekhonin^{2

4}

Affiliations

¹ N. I. Pirogov Russian National Research Medical University, Moscow, Russia. alevtina.semkina@gmail.com.
² N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
³ MISiS National Research Technological University, Moscow, Russia.
⁴ V. P. Serbsky Federal Medical Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
⁵ N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia.
⁶ MIFI National Research Nuclear University, Moscow, Russia.

PMID: 28429228
DOI: 10.1007/s10517-017-3718-x

Abstract

We studied the possibility of using BSA-coated magnetic iron oxide nanoparticles for magnetic resonance imaging diagnosis of C6 glioblastoma, 4T1 mammary adenocarcinoma, and RS-1 hepatic mucous carcinoma. In all three cases, magnetic nanoparticles accumulated in the tumor and its large vessels. Magnetic resonance imaging with contrast agent allows visualization of the tumor tissue and its vascularization.

Keywords: cancer; magnetic nanoparticles; magnetic resonance imaging (MRI); tumor; tumor vessels.

MeSH terms

Adenocarcinoma / diagnostic imaging*
Adenocarcinoma / metabolism
Adenocarcinoma, Mucinous / diagnostic imaging*
Adenocarcinoma, Mucinous / metabolism
Animals
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / metabolism
Cell Line, Tumor
Contrast Media / chemistry
Contrast Media / pharmacokinetics*
Female
Ferric Compounds / administration & dosage
Ferric Compounds / chemistry
Glioma / diagnostic imaging*
Glioma / metabolism
Injections, Subcutaneous
Liver Neoplasms / diagnostic imaging*
Liver Neoplasms / metabolism
Magnetic Resonance Imaging / methods
Magnetite Nanoparticles / administration & dosage*
Mammary Neoplasms, Experimental / diagnostic imaging*
Mammary Neoplasms, Experimental / metabolism
Mice
Mice, Inbred BALB C
Rats
Rats, Wistar

Substances

Contrast Media
Ferric Compounds
Magnetite Nanoparticles
ferric oxide